International immunopharmacology
Neogambogic acid promotes M-MDSC differentiation into M1 macrophages to inhibit peritoneal metastasis of colorectal cancer.
Jinjin Liu, Zhao Wu, Jing Xun, Xiaolin Jiang, Bin Liu, Huichao Yang, Yingdi Han, Zhibo Hu, Qi Gao, Ai'min Zhang, Shimin Yang, Xiangyang Yu, Qi Zhang
Published: 202610.1016/j.intimp.2026.116255
Abstract
BACKGROUND: The immunosuppressive microenvironment severely constrains the efficacy of immunotherapy for colorectal cancer with peritoneal metastasis (CPM), urgently demanding strategies to reprogram it. Here, we aim to evaluate natural compound neog…
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