International immunopharmacology
FGL1 modulates macrophage function and enhances liver repair through LAG3-TNFR1 axis.
Yuzhe Wu, Qinghua Fang, Yanyun Chen, Liqiu Huang, Wenjun Zhang, Yuan Huang, Xinfeng Xu, Xin Chen, Fang Wu, Wei Xu
Published: 202610.1016/j.intimp.2026.116209
Abstract
Fibrinogen-like protein 1 (FGL1), a liver-derived secretory factor, functions as a major histocompatibility complex class II (MHC-II)-independent ligand for lymphocyte activation gene 3 (LAG3), potentially offering protection against liver damage. Ho…
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