International immunopharmacology
Identification of Siglec-15 as a novel target for CAR-T cell therapy in acute myeloid leukemia.
Haidong Cui, Chenyang Zhao, Ting Li, Chongkai Wang, Yan Wang, Lingling Shan, Xiaoming Feng, Xiaofen Qiu, Xiaoli Chen
Published: 202610.1016/j.intimp.2026.116170
Abstract
Chimeric antigen receptor (CAR)-modified T cells have demonstrated notable success in treating B-cell malignancies. However, applying CAR T-cell therapy to acute myeloid leukemia (AML) poses considerable challenges, primarily due to the extensive phe…
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