International immunopharmacology
Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss.
Jingguo Chen, Han Yin, Zijian Yan, Kejia Shang, Xinyan Li, Handi Li, Shuai Zhou, Chen Feng, Yingze Zhang, Qi Zhang
Published: 202610.1016/j.intimp.2026.116168
Abstract
With aging, the responsiveness of bone tissue to mechanical loading progressively declines, leading to altered bone homeostasis and continuous bone loss. Piezo1, a recently identified mechanosensitive calcium channel, plays a critical role in bone de…
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