International immunopharmacologyPhosphoglycerate KinaseBlood-Brain BarrierTOR Serine-Threonine KinasesProto-Oncogene Proteins c-aktAnimals
PGK1 contributes to blood-brain barrier integrity via PI3K-AKT-mTOR pathway in early pneumococcal meningitis.
Xiao-Hui Liu, Feng Hao, Shu-Xin Zhao, Xiao-Mu Guo, Xiao-Qing Shi, Hui-Wen Geng, Zhuo Zhang, Yong-Juan Xin, Bing Huang, Pei-Pei Liu
Published: 202610.1016/j.intimp.2026.116163
Abstract
Pneumococcal meningitis continues to be a devastating disease associated with high mortality and neurological sequelae, largely due to disruption of the blood-brain barrier (BBB). Emerging evidence implicates that metabolic reprogramming within the n…
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