International immunopharmacologyAnimalsGastrointestinal MicrobiomeTh17 CellsT-LymphocytesRegulatory
Astragaloside IV alleviates ulcerative colitis via gut microbiota - butyrate metabolism axis to reshape Th17/Treg balance.
Youbao Zhong, Jing Liu, Jiaqi Huang, Ji Yu, Yazhen Liu, Wang Zhuo, Youhui Xu, Yixi Zhang, Zhiyu Zhou, Liling Chen, Qiuping Xiao, Duanyong Liu
Published: 202610.1016/j.intimp.2025.116135
Abstract
Gut microbiota dysbiosis and Th17/Treg cell imbalance play critical roles in the pathogenesis of ulcerative colitis (UC). Astragaloside IV (AS-IV) exhibits extensive anti-inflammatory and immunomodulatory activities; however, the crosstalk between gu…
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