International immunopharmacologyHumansAsthmaX-Box Binding Protein 1AnimalsEndoplasmic Reticulum Stress
ERN2/XBP1-AGR2 mediated endoplasmic reticulum stress increased neutrophilic asthma mucus secretion.
Jing Yang, Xiaofang Li, Bei Ye, Zhiyan Luo, Huiting Huang, Xiaoyun Peng, Wujin Wen, Gang Liao, Huiqiu Liang, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang
Published: 202610.1016/j.intimp.2025.116133
Abstract
A major pathogenic mechanism of neutrophilic asthma (NA) may be the excessive secretion of mucus, which causes variable degrees of airflow obstruction. This study showed the critical role of endoplasmic reticulum stress response (ERS) in NA mucus hyp…
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