International immunopharmacologyAnimalsMorphinansArthritisRheumatoidArginase
Targeting the MDSC-Th17 axis: Sinomenine suppresses rheumatoid arthritis by disrupting arginase-1-mediated immune crosstalk.
Xiangyun Meng, Hao Wang, Xiaoyun Chen, Zhiqian Huang, Haocai Luo, Ruoyuan Li, Guiping Lin, Meng Li, Fei Zhong, Xiang-Yang Wang, Junqing Zhu, Juan Li, Shixian Chen
Published: 202610.1016/j.intimp.2025.116104
Abstract
Myeloid-derived suppressor cells (MDSC) play a critical role in rheumatoid arthritis (RA) pathogenesis by promoting Th17 cell polarization toward a pro-inflammatory and pro-osteoclastogenic phenotype. Sinomenine (SIN) is an effective anti-inflammator…
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