International immunopharmacologyNucleus PulposusIntervertebral Disc DegenerationHumansOsteopontinMale
SPP1 secreted by nucleus pulposus cells mediates inflammatory infiltration and contributes to intervertebral disc degeneration.
Yili Xu, Yao Wu, Zuozhi Xie, Jinfeng Wang, Ruxue Xu, Tao Xu, Shubo Gu, Zhenhua Feng, Zezhang Zhu, Yong Qiu, Junlai Wan, Bo Shi, Jun Jiang
Published: 202610.1016/j.intimp.2025.116099
Abstract
Low back pain resulting from intervertebral disc degeneration has emerged as a global public health challenge, imposing a substantial economic and societal burden. The inflammatory response of nucleus pulposus cells and the imbalance of the extracell…
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