International immunopharmacologyHumansCarcinomaHepatocellularLiver NeoplasmsMethylenetetrahydrofolate Dehydrogenase (NADP)
UBE2C-PI3K/AKT-mediated upregulation of MTHFD2 promotes tumor progression in hepatocellular carcinoma.
Yingying Tong, Qian Liu, Zezhou Zhao, Kangjie Wang, Jing Wang, Baojuan Han, Ke Zhu, Lijun Yang, Chan Zhang, Dong Guo, Dong Yan, Xin Liu
Published: 202610.1016/j.intimp.2025.116081
Abstract
Hepatocellular carcinoma (HCC) is a highly aggressive liver malignancy with poor prognosis and limited therapeutic options. Methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2), a mitochondrial enzyme involved in one‑carbon metabolism, i…
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