International immunopharmacologyAnimalsAcute Lung InjuryDexmedetomidineMustard GasMice
Repurposing the anesthetic dexmedetomidine: a novel antidote for sulfur mustard analog-induced acute lung injury via multi-mechanism modulation.
Min-Jie Shi, Jiang-Zheng Liu, Wei-Hua Yu, Rui Liu, Lu-Yao Li, Meng Cao, Yun-Ze Tian, Xiao-Di Zhang, Hao Wu, Jian-Zhong Li, Chun-Xu Hai, Wen-Li Li, Jia Li, De-Qin Kong
Published: 202610.1016/j.intimp.2025.116069
Abstract
Sulfur mustard (SM), a typical alkylating agent, poses significant threats. Inhalational SM exposure causes acute lung injury (ALI) with complex mechanisms and no effective antidotes. we established a murine inhalation model and an in vitro alveolar…
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