International immunopharmacologyAnimalsOsteogenesisDiabetes MellitusType 2Osteoporosis
Elabela APJ Axis attenuates type II diabetes osteoporosis by enhancing the coupling of H-type angiogenesis and osteogenesis.
Run-Xun Ma, Yang-Fan Guo, Si-Xiang Feng, Yi-Xun Huang, Li-Bo Pan, Yi-Tian Bu, Yi-Kai Wang, Jian Luo, Bing-Hao Lin, Lei Yang
Published: 202610.1016/j.intimp.2025.116068
Abstract
BACKGROUND: Type 2 diabetes-related osteoporosis (T2DOP) is intricately connected to microvascular degeneration, particularly the loss of H-type vessels involved in osteogenesis-angiogenesis coupling. Elabela (ELA), a crucial APJ receptor ligand, reg…
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