International immunopharmacologyAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinRetinal NeovascularizationInflammasomes
The NLRP3 inflammasome inhibitor OLT1177 attenuates retinal neovascularization and microglial inflammation with neuroprotective effects.
Peiqi Wu, Xiaoyu Tang, Kaixuan Cui, Andina Hu, Boyu Yang, Xi Lu, Fengmei Yang, Jicheng Lin, Haolin Kong, Shanshan Yu, Yue Xu, Xiaoling Liang
Published: 202610.1016/j.intimp.2025.116066
Abstract
Nucleotide-binding oligomerization domain like receptor protein 3 (NLRP3) inflammasome is considered as a critical contributor to pathological angiogenesis and neuronal dysfunction. However, its role in ischemic retinopathies remains unclear. In this…
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