International immunopharmacologyAnimalsMetforminMaleEndotoxemiaRats
Metformin diminishes lipopolysaccharide-induced endotoxemia and cardiopulmonary microvascular coagulopathy: Molecular insights on vascular endothelial growth factor-A and its receptors.
Shereen E Elkholy, Enas M A Mostafa, Angie M Ameen, Eman Z Abdelaziz, Eman R Hamed, Mohamed K El-Kherbetawy, Heba A Elsayed, Rasha Atta, Wagdy Abdelfatah, Amir E Mehana, Mohamed A Tantawy, Rama I Mahran, Samah M Elaidy
Published: 202610.1016/j.intimp.2025.116036
Abstract
Vascular endothelial growth factor (VEGF)-A, a hypoxia- and cytokine-inducible biomarker of endothelial activation, together with its receptors VEGFR1 and VEGFR2, contributes to endotoxemia and early sepsis-related vascular dysfunction by increasing…
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