International immunopharmacologyAnimalsSarcopeniaCD36 AntigensFemaleMice
Emodin attenuates estrogen-deficient sarcopenia by suppressing CYP1B1 to restore CD36-driven fatty acid handling in muscle stem cells.
Jingbo Xie, Pengchao Xu, Zhefei Xie, Weixiang Wang, Jiangyuan Liu, Tianyou Ma, Yiwen Yang, Rui Xu, Fan Wu, Hui Jian, Hanting Xia
Published: 202610.1016/j.intimp.2025.116028
Abstract
Sarcopenia is a progressive, estrogen-deficiency-related syndrome characterized by the loss of muscle mass and regenerative capacity, particularly in postmenopausal women. We identify Emodin, a natural anthraquinone compound, as a potent metabolic mo…
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