International immunopharmacologyAnimalsAsthmaAntigensDifferentiationT-Lymphocyte
CD11c+CD69+ trained APCs in lungs mediate allergic asthma through increased H3K27ac.
Wenjian Li, Junhai Wang, Hanglin Li, Boyang Zheng, Beibei Qin, Xiaoying Wang, Ling Zhang, Jiaqi Liang, Jiao Li, Yueling Wang, Yuqing Deng, Xiaoqing Zheng, Ruihong Zeng
Published: 202610.1016/j.intimp.2025.116021
Abstract
OBJECTIVE: Investigating the impact and mechanism of trained antigen-presenting cells (APCs) in asthma in ovalbumin (OVA)-sensitized mouse model and discovering targets for treating asthma. METHODS: BALB/c and C57BL/6 J wild-type mice and TNF-α-/- mi…
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