International immunopharmacologyAnimalsLiraglutideEndoplasmic Reticulum StressSirtuin 1Glucagon-Like Peptide-1 Receptor Agonists
GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathway.
Xiong Zhang, Ruimin Chi, Jingting Xu, Chen Meng, Zhenggang Wang, Wanjun Ruo, Fei Xin, Tao Xu, Fengjing Guo, Genchun Wang, Yaping Ye
Published: 202610.1016/j.intimp.2025.116010
Abstract
Rotator cuff injuries are a common cause of shoulder pain with limited treatment options. Recent studies highlight inflammation's role in tendinopathy. GLP-1R agonists have shown anti-inflammatory effects in various diseases, but their role in rotato…
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