International immunopharmacologyExtracellular TrapsPyroptosisHumansSepsisAnimals
Neutrophil extracellular traps induce hepatocyte pyroptosis via CCDC25 in sepsis-associated liver injury.
Zhiyu Li, Yumeng Xiao, Lan Yang, Fengming Liang, Hongyang Xu, Fei Gao
Published: 202610.1016/j.intimp.2025.115991
Abstract
Clinical data reveal that elevated neutrophil extracellular traps (NETs) in sepsis-associated liver injury (SALI) patients strongly correlate with increased liver enzymes (NET-DNA vs. ALT/AST: r2 = 0.6727/0.8884) and predict higher 90-day mortality.…
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