International immunopharmacologyNLR FamilyPyrin Domain-Containing 3 ProteinAnimalsNIMA-Related KinasesInflammasomes
Nimbolide inhibits NLRP3 inflammasome activation via blocking NEK7-NLRP3 interaction and alleviates sepsis-induced lung injury.
XueYi Wang, JunMei Li, BoWen Yu, HuanHuan Gong, ZhanChuan Li, Yang Bai
Published: 202610.1016/j.intimp.2025.115954
Abstract
BACKGROUND: Sepsis-associated acute lung injury (ALI) remains a critical clinical challenge with limited therapeutic options. The NLRP3 inflammasome drives pathological inflammation in ALI, yet clinical translation of existing inhibitors is hindered…
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