International immunopharmacologyAnimalsTwist-Related Protein 1HarmineHumansFibrosis
Harmine attenuates renal fibrosis via Twist1 suppression: A novel anti-fibrotic strategy for chronic kidney disease with efficacy/safety profiling.
Liuyifei Huang, Jingli Gao, Yan Xing, Xiaoxuan Ning, Lei Wei, Peng He, Yifan Yang, Xiao Bai, Limin Liu, Shiren Sun
Published: 202610.1016/j.intimp.2025.115902
Abstract
Renal fibrosis, a pathological hallmark of chronic kidney disease (CKD), accounts for over 40 % of end-stage renal disease cases globally, with IgAN nephropathy and diabetic nephropathy representing >60 % of progressive CKD subtypes. Despite its clin…
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