International immunopharmacologyAnimalsReperfusion InjuryReactive Oxygen SpeciesNecroptosisReceptor-Interacting Protein Serine-Threonine Kinases
Obacunone inhibits RIPK1/RIPK3/MLKL-mediated necroptosis by suppressing mitochondrial ROS and MIF signaling in intestinal ischemia-reperfusion injury.
Xiao-Yao Li, Jing-Yuan Xie, Yu-Tong Yin, Xiao-Guo Weng, Zi-Yi Huang, Lu-Si Wang, Ke Ding, Rong Chen, Qing-Tao Meng
Published: 202610.1016/j.intimp.2025.115901
Abstract
BACKGROUND: Intestinal ischemia-reperfusion (IIR) is a critical pathophysiological event associated with high morbidity and mortality, often leading to intestinal barrier disruption and systemic inflammatory responses. Obacunone (OBA), a naturally oc…
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