International immunopharmacologyAnimalsMiceNF-kappa BRAW 264.7 CellsToll-Like Receptor 4
Bomidin prevents inflammatory responses in macrophages by inhibiting toll-like receptor 4/nuclear factor-κB activation and blocking metabolic reprogramming to alleviate periodontal inflammation.
Shanshan Ma, Jin Wu, Fang Yuan, Rongping Nie, Guoqing Li, Zixiang Guo, Wei Wu, Chunbo Tang
Published: 202610.1016/j.intimp.2025.115900
Abstract
Macrophages play an important role in the pathogenesis and prognosis of periodontitis, a complex immune-inflammatory disease that causes gingival inflammation and alveolar bone loss. Bomidin, a novel recombinant antimicrobial peptide known for its po…
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