International immunopharmacologyAnimalsOsteolysisMiceRNA-Binding ProteinsInbred C57BL
Periprosthetic osteolysis is mediated by the m6A-dependent regulation of CEMIP via YTHDF2.
Zeming Lei, Yansheng Wang, Liangzi Yin, Ziyuan Wang, Lunhao Bai
Published: 202610.1016/j.intimp.2025.115895
Abstract
Wear particle-induced periprosthetic osteolysis (PPO) represents the primary reason for implant failure following joint replacement, driven by macrophage polarization and excessive osteoclastogenesis. While cell migration inducing hyaluronidase 1 (CE…
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