International immunopharmacologyPyroptosisNLR FamilyPyrin Domain-Containing 3 ProteinExtracellular MatrixHumans
T-2 toxin exacerbates chondrocyte extracellular matrix degradation potentially through YAP/NLRP3/GSDMD-mediated pyroptosis.
Haonan Li, Zhifeng Xing, Hexuan Dong, Fang Qi, Qian Yu, Jiaxin Li, Hong Jiang, Chenxi Wang, Jiayuan Li, Bing Zhang, Jun Yu
Published: 202610.1016/j.intimp.2025.115890
Abstract
Kashin-Beck disease (KBD) is an endemic osteoarthropathy, with T-2 toxin recognized as a major pathogenic factor. This study investigates the role of the YAP/NLRP3/GSDMD signaling pathway in T-2 toxin-induced cartilage injury. Differentially expresse…
Preview only. Read the full abstract at the source