International immunopharmacologyAnimalsMegakaryocytesZebrafishCell DifferentiationMice
Ginkgolic acid: a novel IL1R1 agonist facilitating megakaryocyte differentiation and platelet production via the SRC/MEK/ERK pathway.
Yi Wang, Ruixue Liao, Rui Liao, Miao Huang, Peilian Jiang, Zhixuan Liu, Anguo Wu, Feihong Huang, Qianqian Huang, Jiesi Luo, Long Wang, Jianming Wu
Published: 202610.1016/j.intimp.2025.115884
Abstract
Thrombocytopenia, a common complication of prolonged radiotherapy in cancer patients, presents significant clinical management challenges due to limitations of current therapies. In this study, we screened Ginkgolic acid (GA) and elucidated its mecha…
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