International immunopharmacologyAnimalsFlavonoidsAutophagyTOR Serine-Threonine KinasesProto-Oncogene Proteins c-akt
Baicalin inhibits the Akt/mTOR/ULK1 signaling pathway to activate autophagy and ameliorate pulmonary fibrosis.
Xu-Liang Hu, Qing Liang, Zhi-Jun Jie, Wan-Sheng Chen, Jiu-Ling Deng, Guang-Chun Sun
Published: 202610.1016/j.intimp.2025.115883
Abstract
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder pathologically characterized by epithelial-mesenchymal transition (EMT) and aberrant extracellular matrix (ECM) accumulation. Autophagy dysfunction has recently…
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