International immunopharmacologyAnimalsCD8-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorLiver NeoplasmsHumans
PD-1+/CXCR6+CD8+T lymphocytes promote MASLD malignant progression through inflammatory and immune dysregulation.
Yifan Wang, Mengya Zhou, Luyin Liu, Lingling Wang, Minghui Zou, Qun Xie, Dengfu Yao, Min Yao
Published: 202610.1016/j.intimp.2025.115847
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to hepatocellular carcinoma (HCC), but the role of CD8+ T cells from MASLD to HCC progression is unclear. This study investigates the dynamic changes in CD8+ T cells v…
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