International immunopharmacologyDNA DamageHepatocytesMembrane ProteinsNucleotidyltransferasesCarcinoma
Nuclear envelope rupture and DNA damage driven by high pressure are mediated by F-actin and induce hepatocyte inflammation via cGAS-STING.
Jia Luo, Rui Huang, Yun Tu, Siru Zheng, Xiaomei Zhang, Qing Luo, Guanbin Song
Published: 202610.1016/j.intimp.2025.115841
Abstract
Alterations in physical traits of the microenvironment contribute to the progression and malignancy of hepatocellular carcinoma (HCC). As liver inflammation gives rise to the initiation and progression of HCC, it remains largely unknown how mechanica…
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