International immunopharmacologyHSP90 Heat-Shock ProteinsAnimalsPulmonary FibrosisWnt Signaling PathwayTriazoles
Ganetespib as an inhibitor of heat shock protein 90 alleviates pulmonary fibrosis by inhibiting the Wnt/β-catenin signaling pathway.
Zhe Wang, Yunkun Qin, Shuai Song, Xiangyi Qin, Na Wang, Jingjing Xu, Meng Zhou, Fang Zhou
Published: 202610.1016/j.intimp.2025.115837
Abstract
Pulmonary fibrosis, a progressive interstitial lung disease with rising global incidence, currently has limited therapeutic options. Ganetespib is a potent HSP90 inhibitor, has shown anti-fibrotic potential in liver models, but its mechanism in pulmo…
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