International immunopharmacologyAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinSphingosine-1-Phosphate ReceptorsMale
Ticagrelor attenuates cholestasis-induced liver fibrosis by inhibiting S1PR2-dependent Akt/ERK signaling, NLRP3 inflammasome activation.
Walaa H El-Maadawy, Marwa Amer, Amr Mostafa, Abdelrahman A Hassany, Nesma S Shafie, Ahmed W Lethy, Eman El-Ahwany, Ehab Hafiz
Published: 202610.1016/j.intimp.2025.115834
Abstract
S1PR2 activation is a pivotal player in chronic liver disease (CLD) progression through bile acid (BA) and sphingosine-1-phosphate (S1P) signaling. This signaling promotes ductular reaction (DR), NLRP3 inflammasome-driven inflammation, and fibrosis p…
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