International immunopharmacologyAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinPyroptosisMyocardial Reperfusion Injury
UPF1 alleviates myocardial ischemia/reperfusion injury via suppressing NLRP3-mediated cardiomyocyte pyroptosis by inhibiting KLF6/TXNIP axis.
Wei Yan, Momu Liu, Mali Qiu
Published: 202610.1016/j.intimp.2025.115789
Abstract
BACKGROUND: Kruppel-like factor 6 (KLF6) is considered to be a regulator for myocardial ischemia/reperfusion (I/R) injury. Therefore, its role and mechanism deserve further investigation. METHODS: Myocardial I/R injury mice models and hypoxia/reoxyge…
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