International immunopharmacologyAnimalsMicePeritoneal FibrosisReactive Oxygen SpeciesTransforming Growth Factor beta
Macrophage extracellular traps promote peritoneal fibrosis through the ROS/TGF-β/Smad pathway under high-glucose dialysis conditions.
Jiaojiao Wang, Chengyuan Yu, Huiyan Lyu, Tianyuan Liu, Rujue Xie
Published: 202510.1016/j.intimp.2025.115748
Abstract
BACKGROUND: Long-term exposure to peritoneal dialysis fluid (PDF) can lead to peritoneal fibrosis (PF), ultimately compromising dialysis efficacy and patient outcomes. Although macrophage extracellular traps (METs) have been implicated in sterile inf…
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