International immunopharmacologyAnimalsConnexin 43AstrocytesGap JunctionsAcrolein
Trans-cinnamaldehyde alleviates IFN-α-induced depressive-like behaviors by restoring astrocytic Cx43 gap junction.
Run Zhou, Ruolan Yuan, Junrui Ye, Shasha Wang, Yuqi Chen, Xiaofen Zhou, Shifeng Chu, Zhao Zhang, Naihong Chen
Published: 202510.1016/j.intimp.2025.115741
Abstract
Interferon-alpha (IFN-α)-induced depression lacks effective treatments, and its neuroinflammatory mechanisms remain unresolved. Trans-cinnamaldehyde (TCA), a cinnamon-derived bioactive compound with anti-inflammatory properties, was investigated for…
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