International immunopharmacologyAnimalsNFATC Transcription FactorsOsteoclastsBone ResorptionSignal Transduction
Cajanin transcriptionally disrupts the Siglec15/NFATc1 signaling cascade to attenuate osteoclast fusion and bone resorption.
Chao Ma, Liang Mo, Zhangzheng Wang, Wei He, Wei Niu, Stuart B Goodman, L Henry Goodnough, Yuhao Liu
Published: 202610.1016/j.intimp.2025.115726
Abstract
Osteoclast fusion is a critical step for bone resorption, and its dysregulation contributes to pathological bone loss such as postmenopausal osteoporosis. Siglec15, a membrane-bound lectin, has emerged as a key regulator of osteoclast precursor recog…
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