International immunopharmacologyAnimalsObesityMaleMiceInbred C57BL
Pirfenidone regulates obesity-related renal injury through the SIRT3 signaling pathway.
Shan Yang, Cheng Chen, Yang Xiong, Jiaxiu Ling, Lijuan Chen, Chunxia Wang, Xiaoyu Zhang, Jixiu Yi, Wenzhen Deng, Xiaohui Liao
Published: 202510.1016/j.intimp.2025.115709
Abstract
OBJECTIVE: Pirfenidone (PFD) has been used to treat kidney fibrosis. However, the effects of PFD on obesity-related kidney injury and the underlying mechanisms are still poorly understood. METHODS: Male C57BL/6 J mice were fed a high-fat diet (HFD) f…
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