International immunopharmacologyAnimalsB-LymphocytesAsthmaMiceMatrix Metalloproteinase 12
MMP-12 blockade in B lymphocytes inhibits the formation of inducible BALTs and alleviates neutrophilic allergic airway inflammation.
Xijie Zhang, Chen Yang, Min Wang, Qi Yuan, Xinyu Jia, Tingting Xu, Zhengxia Wang, Ningfei Ji, Mao Huang, Mingshun Zhang
Published: 202510.1016/j.intimp.2025.115706
Abstract
Inducible bronchus-associated lymphoid tissue (iBALT), the tertiary immune organ in the lungs, has been implicated in various pulmonary diseases. The formation and roles of iBALTs in neutrophilic allergic asthma, however, remain largely unexplored. I…
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