International immunopharmacologyAnimalsNADPH Oxidase 4PPAR gammaMiceInbred C57BL
Proinflammatory macrophage polarization is driven by NOX4/PPARγ axis-mediated oxidative-inflammatory crosstalk in CEES-induced lung injury.
Meng Cao, Zhen Wang, Hao Wu, Rui Liu, Deqin Kong, Jiangzheng Liu, Zhao Wang, Xiaodi Zhang, Xinyue Xu, Tian Gao, Zi Long, Weihua Yu, Chunxu Hai
Published: 202510.1016/j.intimp.2025.115701
Abstract
Sulfur mustard (SM), a well-known vesicant chemical warfare agent, induces acute lung injury through mechanisms that remain incompletely understood. This study aimed to delineate the specific contributions of oxidative stress and inflammatory pathway…
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