International immunopharmacologyAnimalsBerberineToll-Like Receptor 4Signal TransductionAngiopoietin-2
Berberine attenuates liver fibrosis via inhibition of Ang-2 through the toll-like receptor 4-mediated signaling pathway.
Hong Wang, Yanan Zhou, Wenlu He, Fulan Zhao, Roman Spáčil, Wei Ren, Yining Ma
Published: 202510.1016/j.intimp.2025.115673
Abstract
Liver fibrosis, a key pathological feature in chronic liver injury, accelerates chronic liver disease (CLD) progression to cirrhosis. Fibrogenesis relies on angiogenesis balance, namely, physiological angiogenesis mitigates liver injury while patholo…
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