International immunopharmacologyAnimalsSitagliptin PhosphateFerroptosisNF-E2-Related Factor 2Diabetes Mellitus
Sitagliptin inhibits neuronal ferroptosis to alleviate cognitive dysfunction by activating Nrf2-SLC7A11-GPX4 axis in diabetic mice.
Han Meng, Zhaoyu Xie, Tao Xu, Sasa Kong, Mengting Wang, Qin Zhu, Yu Zhang, Zhixu Zhu, Miaomiao Wu, Yueqiu Wang, Chao Chen, Jun Han, Hui Che
Published: 202510.1016/j.intimp.2025.115672
Abstract
Diabetic cognitive dysfunction (DCD) is one of the major complications of type 2 diabetes mellitus (T2DM). At present, there is still no clinical consensus on the improvement and treatment of DCD, mainly due to limitations in understanding the pathog…
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