International immunopharmacologyHumansReceptorsG-Protein-CoupledEsophageal Squamous Cell CarcinomaTransforming Growth Factor beta
GPRC5A+ myCAFs promote ESCC progression via TGF-β-induced fibroblast activation and ANXA1-mediated M2 macrophage polarization.
Xiang Lv, Ming Liu, Jing Chen, Xiamin He, Jiamiao Weng, Yanhui Lin, Yaocheng Wang, Rongzhao Zhang, Minjian Huang, Lilan Zhao, Fan Lin, Chundong Yu, Yi Huang
Published: 202510.1016/j.intimp.2025.115663
Abstract
Cancer-associated fibroblasts (CAFs) play a pivotal regulatory role in the immune microenvironment of esophageal squamous cell carcinoma (ESCC), reshaping the tumor microenvironment and promoting disease progression through the secretion of various f…
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