International immunopharmacologyAnimalsFerroptosisCoenzyme A LigasesHumansMice
Targeted inhibition of METTL3 reprograms alveolar echinococcosis progression: attenuating ferroptosis by downregulating ACSL4 and reversing macrophage M2 polarization.
Jiahui Chen, Yuyu Ma, Bin Fan, Ning Shi, Yuqin Sun, Xuan Zhou, Haonan Wang, Madinaimu Aibibula, Xiumin Ma, Liang Wang
Published: 202510.1016/j.intimp.2025.115660
Abstract
BACKGROUND: Alveolar echinococcosis (AE) is a severe parasitic disease caused by larval-stage infection of Echinococcus multilocularis (Em), characterized by high mortality and recurrence rates. The interplay between ferroptosis and macrophage polari…
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