International immunopharmacologyQuercetinAnimalsIntervertebral Disc DegenerationMiceExtracellular Matrix
Quercetin alleviates intervertebral disc degeneration by disrupting CEBPB-HMGA1 interaction to suppress TNFA production and reduce ECM degradation.
Ming Liu, Xiaozong Duan, Chaoju Lou
Published: 202510.1016/j.intimp.2025.115654
Abstract
BACKGROUND: Intervertebral disc degeneration (IVDD) is a highly prevalent degenerative disease related to macrophage M1 polarization and nucleus pulposus cells (NPCs) dysfunction. Quercetin is a common flavonoid found in various plants, and its thera…
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