International immunopharmacologyReceptorsImmunologicAnimalsHumansPancreatic Neoplasms
Enhancing anti-tumor immunity through TIGIT blockade and tumor-directed targeting in pancreatic cancer.
Yun Jung Um, Dongwook Kwak, Seok Yung Kim, Hye Jin Chang, Sun Hyung Yum, Junsik Hwang, Ji-Eun Kim, Ji Yun Jung, Shin Hee Hong, Sohyeon Park, Jihye Lee, Seon Ki Kim, Young Sun Oh, Min-Duk Seo, Mi Ran Kim
Published: 202510.1016/j.intimp.2025.115653
Abstract
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to immune checkpoint blockade, driven by a dense stroma, low immunogenicity, and an immunosuppressive tumor microenvironment. T cell immunoreceptor with Ig and ITIM domain (TIGIT) i…
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