International immunopharmacologyPyroptosisFlavonoidsOsteoarthritisMolecular Docking SimulationNLR Family
Exploration of molecular mechanism of baicalin targeting TRIM24 to suppress NLRP3/caspase-1-mediated chondrocyte pyroptosis in osteoarthritis based on network pharmacology and molecular docking.
Guoqi Liu, Hui Jiang, Feng Dai, Wenxi Zhang, Shuguang Ge, Jie Liu
Published: 202510.1016/j.intimp.2025.115646
Abstract
BACKGROUND: Baicalin is a major active ingredient from Scutellaria baicalensis with important roles in various inflammatory diseases, including osteoarthritis (OA). This study aimed to investigate whether baicalin regulates chondrocyte pyroptosis in…
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