Immunity
State-specific enhancer landscapes govern microglial plasticity.
Nicole Hamagami, Dvita Kapadia, Kia M Barclay, Yanlong Huang, Nora Abduljawad, Zuolin Cheng, Liam McLaughlin, Darsh Singhania, Xukai Ding, Jin Yang, Zhixin Sun, Vikram Karra, Siling Du, Peter Bayguinov, Guoqiang Yu
Published: 202610.1016/j.immuni.2025.11.023
Abstract
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging, and disease. Whether these microglial subsets represent ontogenically separate lineages of cell…
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