ImmunityAnimalsReceptorsAntigenT-CellAutoimmunity
The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration.
Xiaoxue Li, Wenhua Liang, Weifang Wang, Eilon Sherman, Keling Huang, Feng Wang
Published: 202610.1016/j.immuni.2025.11.009
Abstract
Aberrant tissue infiltration by activated CD4+ T cells is a central driver of autoimmunity, yet the molecular checkpoints governing antigen-specific T cell ingress remain poorly defined. We found that the transcription factor SUB1 was selectively upr…
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