ImmunityHepcidinsAnimalsMiceIronHumans
A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates.
Yanhui Xu, Xixi Chen, Rongli Fang, Xiaolei Wang, Yanfang Zhang, Huifang Ren, Yunnan Xiao, Yu Ning, Xiaotian Li, Chengwei Chai, Wen Lei, Kanghua Zhong, Jiankun Liang, Qifeng Liang, Yuanyuan Luo
Published: 202610.1016/j.immuni.2025.11.001
Abstract
Systemic rotavirus (RV) infection poses a substantial health challenge in neonates, but the underlying pathogenesis remains elusive. In RV-infected neonatal mice and infants with biliary atresia (BA), we discovered that persistent type I interferon (…
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