ImmunityHumansCD8-Positive T-LymphocytesAnimalsGastrointestinal MicrobiomeNeoplasms
Fermenting T cell stemness for cancer immunity.
Hocheol Shin, Joon Seok Park
Published: 202510.1016/j.immuni.2025.10.018
Abstract
Gut microbial metabolites modulate immune responses to tumors. In this issue of Immunity, Bachem et al.1 demonstrate that microbiota-derived butyrate cooperates with the transcription factor Foxo1 to promote CD8+ T cell stemness and enhance responsiv…
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