ImmunityAnimalsImmunoglobulin EPlasma CellsSpleenMice
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response.
Mariana C G Miranda-Waldetario, Edgar Gonzalez-Kozlova, Edenil C Aguilar, Laura Xie, Kenneth B Hoehn, Carlos J Aranda, Yolanda Garcia-Carmona, Erica G M Ma, Emma S Agudelo, Jamie Redes, Maria A Curotto de Lafaille
Published: 202510.1016/j.immuni.2025.10.011
Abstract
Expression of the IgE BCR is associated with increased B cell apoptosis, yet in persistent allergy, sustained production of IgE antibodies in the absence of allergen exposure suggests the existence of long-lived IgE plasma cells (PCs). Here we studie…
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