Immunology letters
The ever-expanding role of IFI16 in the anti-viral innate immune response.
Hossam Gewaid, Andrew G Bowie
Published: 202610.1016/j.imlet.2026.107139
Abstract
The host PYHIN (pyrin and HIN domain family) protein IFN-γ-inducible protein 16 (IFI16) was first discovered as a nuclear sensor of double-stranded DNA (dsDNA). Since then its roles in innate immunity have expanded to include restriction of infection…
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